RESUMO
COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has threatened every civilian as a global pandemic. The immune system poses the critical interactive chain between the human body and the virus. The current study aimed to assessment whether comorbidity with type 2 diabetes (T2D) affects the immunological response in COVID-19 patients. This case-control study (comparative) was carried out in Baghdad Al-karkh hospitals/ isolation units for Patients covid19, which included 90 subjects from November 2021 to the end of April 2022, as of which 30 participants were with T2D patients, 30 were T2D patients suffer of covid-19, with positive RTPCR for covid-19 and the remaining 30 were nondiabetic (NDM) of aged (50-85) years. To study Ferritin, D-dimer, HbA1c, blood urea(BU), and serum creatinine . The current study showed a significant increase in IL-6 (362.4 +/- 60.01pg/ml), IL-2R beta (8.8 +/- 2.7%), PCT (205 +/- 25.7mg/dl), T2D with COVID-19 patients compared to the control group ( 222.8 +/- 30.7pg/ml, 4.6 +/- 1.3%, 99 +/- 15.1mg/dl, 35 +/- 9.6mg/dl, 0.65 +/- 0.03mg/dl respectively, at the probability value (P<0.05). The COVID-19 patients comorbid with T2D demonstrated distinguishable immunological parameters, which represented clinical relevancies with the predisposed disease severity in T2D.
RESUMO
COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has threatened every civilian as a global pandemic. The immune system poses the critical interactive chain between the human body and the virus. The current study aimed to assessment whether comorbidity with type 2 diabetes (T2D) affects the immunological response in COVID-19 patients. This case-control study (comparative) was carried out in Baghdad Al-karkh hospitals/ isolation units for Patients covid-19, which included 90 subjects from November 2021 to the end of April 2022, as of which 30 participants were with T2D patients, 30 were T2D patients suffer of covid-19, with positive RT-PCR for covid-19 and the remaining 30 were nondiabetic (NDM) of aged (50-85) years. To study concentrations of Interleukin 6( IL-6), Interleukin 2 Receptor Beta (IL-2R beta), Procalcitonin (PCT), Ferritin, D-dimer, HbA1c, blood urea(BU), and serum creatinine . The current study showed a significant increase in IL-6 (362.4+/-60.01pg/ml), IL-2R beta (8.8+/-2.7%), PCT (205+/-25.7mg/dl), Ferritin(), D-dimer(), HbA1c(), blood urea(58+/-12.7mg/dl), and serum creatinine (1.1+/-0.2mg/dl) in T2D with COVID-19 patients compared to the control group (222.8+/-30.7pg/ml, 4.6+/-1.3%, 99+/-15.1mg/dl, 35+/-9.6mg/dl, 0.65+/-0.03mg/dl respectively, at the probability value (P<0.05). The COVID-19 patients comorbid with T2D demonstrated distinguishable immunological parameters, which represented clinical relevancies with the predisposed disease severity in T2D.Copyright © 2022 Mohan R, et al.